Objective To research the effects and mechanism of Weiwei Granules on chronic atrophic gastritis（CAG）. Methods Totally 50SD rats were randomized into the normal group

model group and Weiwei Granules low-dose（1.8g/d）

middle-dose（3.6g/d）and high-dose（7.2g/d）groups

with 10in each.The CAG models were established in all groups except the normal group with comprehensive method.The intragastric administration lasted for 12weeks.The expressions of Bcl-2and proliferating cell nuclear antigen（PCNA）in mucosa of CAG rats were observed with immunohistochemical method. Results Comparing with the model group

the OD values of Bcl-2in Weiwei Granules groups were significantly decreased（P<0.01）.Comparing with the Weiwei Granules low-dose group

the OD value was significantly decreased in the middle-dose group（P<0.01）.Comparing with the Weiwei Granules middle-dose group

the OD value was significantly decreased in the high-dose group（P<0.01）.Comparing with the model group

the positive expression rate of PCNA in Weiwei Granules groups were significantly decreased（P<0.01）.Comparing with the Weiwei Granules low-dose group

the positive expression rate of PCNA was significantly decreased in the middle-dose group（P<0.01）.Comparing with the Weiwei Granules middle-dose group

the positive expression rate of PCNA was significantly decreased in the high-dose group（P<0.01）. Conclusion Weiwei Granules can relieve the pathological state of gastric mucosal lesions and avoid stomach cancer possibly by inhibiting the expressions of Bcl-2and PCNA in mucosa of CAG rats and regulating the proliferation and apoptosis of cells.