Objective To observe the efficacy of Yishen Gukang Formula（ formula for benefiting kidney and bone

益肾骨康方） for metastatic bone cancer and its effect on quality of life（QOL）. Methods Totally 120 cases of metastatic bone cancer were randomized into the treatment group and control group

with 60 in each. Both groups were given intravenous infusion of 90ml Pamidronate Disodium Injection once monthly for 3 months. The treatment group was added with Yishen Gukang Formula one dose daily for 3 months. The physical condition

pain degree

and symptom scores in two groups were evaluated before and after treatment. Results The total efficacy of the treatment group and control group was 23. 33% and 16. 67% respectively

with no significant difference between groups（ P >0. 05）. The clinical benefit rate in the treatment group and control group was 76. 67% and 50. 00% respectively

with a significant difference between groups（ P < 0. 05）. The scores of aching waist and knees

dry mouth and throat

hot flashes

night sweats

irritability

insomnia

pain and thrombocytosis in the treatment group were significantly decreased after treatment（P < 0. 05 or P < 0. 01）. The scores of dry mouth and throat and pain in the treatment group were significantly lower than those in the control group（P < 0. 01）. The steady improvement rate of physical condition in the treatment group and control group was 76. 67% and 50. 00% respectively

with a significant difference between groups（P < 0. 05）. Conclusion The combo therapy of Yishen Gukang Formula and Pamidronate Disodium Injection is effective for metastatic bone cancer. It can obviously relieve pain and symptoms and improve the clinical benefit rate and QOL.