Objective To research the efficacy and safety of self-made Xiaobai Decoction（ decoction for inhibiting vitiligo） combined with Compound Glycyrrhizin and Compound Kali Ziran Tincture for children with vitiligo.Methods Totally 144 children vitiligo were randomized into the treatment group of 90 children and control group of54 children. The treatment group was given self-made Xiaobai Decoction one dose daily

1 tablet（ 25 mg） Compound Glycyrrhizin three times daily and topical application of Compound Kali Ziran Tincture twice daily. The control group was given the same treatment but the decoction. One treatment course lasted for 3 months. The efficacy and TCM syndrome efficacy were observed and compared after treatment. Results There were 22 cases（ 24. 44%） cured

49cases（ 54. 44%） markedly effective

15 cases（ 16. 67%） improved and 4 cases（ 4. 45%） invalid in the treatment group

with a markedly effective rate of 78. 88% and total effective rate of 95. 55%. There were 5 cases（ 9. 26%）cured

17 cases（ 31. 48%） markedly effective

22 cases（ 40. 74%） improved and 10 cases（ 18. 52%） invalid in the control group

with a markedly effective rate of 40. 74% and total effective rate of 81. 48%. There were significant differences between groups in the markedly effective rate and total effective rate（ P < 0. 05 or P < 0. 01）. There was no significant difference between different TCM syndromes in the markedly effective rate and total effective rate in the treatment group（ P > 0. 05）. There was no adverse reaction in both groups during the treatment. Conclusion The combo therapy of self-made Xiaobai Decoction

Compound Glycyrrhizin and Compound Kali Ziran Tincture is effective and safe for children with vitiligo.