Objective To observe the efficacy of integrative medicine for refractory epistaxis. Methods Ninety cases of refractory epistaxis were randomized into the nasal endoscopy group

amoxicillin group and Yiqing Capsules group

with 30 in each. The nasal endoscopy group was given nasal endoscopy microwave treatment. The amoxicillin group was given 0. 5 g of amoxicillin three times daily for 3 to 5 days on the basis of nasal endoscopy group. The Yiqing Capsules group was given 1 g of Yiqing Capsules three times daily for 2 weeks on the basis of amoxicillin group.The levels of urokinase plasminogen activator（ uPA）

uPA receptor（ uPAR）

prothrombin time（ PT）

activated partial thromboplastin time（ APTT）

thrombin time（ TT） and FIBrinogen（ FIB） were detected before and after treatment. The efficacy and cure rate were observed. Results The total effective rate of Yiqing Capsules group and nasal endoscopy group was 90. 0% and 63. 3% respectively

with a significant difference between groups（ P < 0. 05）.The total effective rate of amoxicillin group was 80. 0%

with no significant difference comparing with Yiqing Capsules group（ P > 0. 05）. The one-time cure rate in the Yiqing Capsules group was significantly higher than that in the nasal endoscopy group and amoxicillin group（ P < 0. 05）. After treatment

the levels of uPA

PT and FIB were significantly improved in the nasal endoscopy group

the levels of uPA

PT

APTT and FIB were significantly improved in the amoxicillin group and the levels of uPA

uPAR

PT

APTT

TT and FIB were significantly improved in the Yiqing Capsules group（ P < 0. 05）. Comparing with the nasal endoscopy group and amoxicillin group

the levels of uPA

uPAR

APTT

TT and FIB were significantly improved in the Yiqing Capsules group after treatment（ P < 0. 05）.Comparing with the nasal endoscopy group

the PT level in the Yiqing Capsules group was significantly improved（ P <0. 05）. Conclusion Integrative medicine is effective for refractory epistaxis. It can improve clinical outcomes and coagulation.