Objective To observe the therapeutic effect of ursodeoxycholic acid（ UDCA） combined with Xixian Erhuang Decoction for primary biliary cirrhosis（ PBC）. Methods Eighty cases of PBC were randomized into the treatment group and control group

with 40 in each. The control group was given 13 to 15 m /g（ kg·d） UDCA Capsules and 50 mg Compound Glycyrrhizin Tablets three times daily for 2 weeks. The treatment group was added with Xixian Erhuang Decoction one dose daily. The treatment lasted for 24 weeks. The efficacy

TCM syndrome scores and liver function were observed in both groups after 12-week and 24-week treatment. Results The total TCM syndrome scores in both groups were significantly decreased after 12-week and 24-week treatment（ P < 0. 05 or P <0. 01）

especially in the treatment group（ P < 0. 05 or P < 0. 01）. The complete response rate in the treatment group was significantly higher than that in the control group（ P < 0. 05 or P < 0. 01）. The levels of alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST）

alkaline phosphatase（ ALP）

gamma-glutamyl transpeptidase（ GGT）

total bilirubin（ TBIL） and total bile acid（ TBA） were significantly decreased in both groups after 12-week and 24-week treatment（ P < 0. 05）

especially in the treatment group（ P < 0. 01）. The albumin level was significantly increased in the treatment group after 24-week treatment（ P < 0. 05）

with a significant difference between groups（ P <0. 01）. Conclusion The combo therapy of UDCA and Xixian Erhuang Decoction is effective for PBC. It can obviously relieve symptoms and improve liver function with a better long-term effect as compared with single application of UDCA.