ZHANG Zhongjing was good at treating emotional disorders with formulas contained Guizhi（ cassia twig including cinnamon） in Shanghan Lun（ Treatise on Cold Pathogenic Diseases） and Jingui Yaolue（ Synopsis of Golden Chamber）. ZHANG Zhongjing often used a large amount of Guizhi to treat depression but smaller amount of Guizhi to treat mania. This study can rich the treatment of emotional disorders and truly reflect ZHANG Zhongjing’s medication experience. It is conducive to carry out clinical and research work and find specific drugs with exact efficacy as well.