Objective To observe the efficacy of Stasis-Transforming Toxin-Resolving Formula（ STF） combined with insulin for patients with type 2 diabetes under stress. Methods Seventy patients with type 2 diabetes under stress were randomized into the treatment group of 38 patients and control group of 32 patients. Both groups were given insulin. The treatment group was added with STF. The treatment lasted for 14 days. The blood glucose

blood glucose control time

daily insulin dose

hypoglycemia and large amplitude of glycemic excursions（ LAGE） were observed.Results The level of blood glucose was significantly decreased after treatment in both groups（ P < 0. 01）. There was no significant difference between groups in the level of blood glucose at the same time point after treatment（ P >0. 01）. Comparing with the control group

the daily insulin dose was significantly decreased

the blood glucose control time was significantly shortened

the incidence of hypoglycemia was significantly reduced

and LAFE was significantly decreased in the treatment group（ P < 0. 05）. Conclusion The combo therapy of STF and insulin is effective for patients with type 2 diabetes under stress. It can obviously shorten the blood glucose control time and reduce the daily insulin dose

hypoglycemia occurrence and glucose fluctuation range.