Objective To observe the therapeutic effect of Chinese medicine bath therapy combined with Danshen Injection intravenous drip in treating generalized plaque psoriasis. Methods Totally 89 cases of generalized plaque psoriasis were randomized into the observation group of 53 cases and control group of 36 cases. Patients in the observation group were treated by Chinese medicine bath therapy（ Danshen stasis-removing lotion） together with Danshen intravenous drip. The patients in the control group were orally taken acitretin capsules. In both groups

rash area was bandaged with calcipotriol cream and applied with mometasone furoate cream. The clinical efficacy of both groups was observed after 2-week treatment. After treatment

Psoriasis area and severity index（ PASI） scores of the 3rd day

the 1st week and the 2nd week were compared. Results PASI scores of the observation group after three-day

oneweek and two-week treatment were significantly decreased as compared with those before treatment（ P < 0. 05）. PASI scores of the control group after one-week and two-week treatment were significantly decreased as compared with those before treatment（ P < 0. 05）. There was no significant difference between groups in PASI scores after three-day

oneweek and two-week treatment（ P > 0. 05）. The total effective rate of the observation group and control group after three-day treatment was 13. 21% and 8. 33% respectively

with a statistical significance between groups（ P < 0. 05）.There was no significant difference between groups in the total effective rate after one-week and two-week treatment（ P >0.05）. Conclusion Compared with acitretin capsules

Chinese medicine bath therapy combined with Danshen intravenous drip has similar clinical effect in treating generalized plaque psoriasis. In addition

this method has few side-effects but quick action.