Objective To observe the efficacy and safety of Liver-Nourishing Enzyme-Declining Mixture（ LEM）on chronic hepatitis B. Methods Totally 80 cases of chronic hepatitis B were randomized into the treatment group and control group

with 40 in each. The treatment group was given LEM

30 ml /time and 3 times daily. The control group was given Diammonium Glycyrrhizinate Enteric-Coated Capsules

3 capsules /time and 3 times daily. The treatment course in both groups lasted for 3 months. The efficacy was observed

the TCM symptom score was compared and the levels of alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST） and α-glutamyl transpeptidase（ GGT） were detected. The adverse reactions were observed. Results The total effective rate of the treatment group and control group were 82. 5% and 75. 0% respectively

with a significant difference between groups（ P <0. 05）. After treatment

the scores of poor appetite

epigastric distension and depression

lassitude

rib-side pain

soreness and weakness of waist and knees

and dysphoria in chestpalms-soles were significantly decreased in both groups（ P < 0. 05）

especially in the treatment group（ P < 0. 05）. The levels of ALT

AST and GGT in both groups were significantly improved after treatment（ P < 0. 05）

especially in the treatment group（ P < 0. 05）. The number of cases with normal safety index in the treatment group was larger than those in the control group（ P < 0. 05）.Conclusion LEM is effective and safe for chronic hepatitis B.