Objective To observe the influence of Jianpi Qinghua Formula on renal function of chronic renal failure（ CRF） patients with spleen deficiency and dampness-heat syndrome and the possible anti-micro-inflammation mechanism of the formula. Methods Seventy cases of CRF patients were randomly divided into a traditional Chinese medicine（ TCM） group and a western medicine group

with 35 cases in each. Another 10 people with healthy physical examination results were admitted into a healthy control group. Patients of two groups were given conventional western medicine treatment

while in addition

the TCM group was treated with Jianpi Qinghua Formula.After a 12-week treatment

serum creatinine（ Scr） and 24-hour urine protein quantity in two groups were tested. Levels of C reactive protein（ CRP）

interleukin-6（ IL-6） and advanced glycationend products（ AGEs）. were compared in three groups. Results Levels of CRP

IL-6 and AGEs in both TCM group and western medicine group were significantly higher than that in healthy control group before treatment（ P < 0. 05）. After treatment

levels of Scr

CRP

IL-6

and AGEs in TCM group were significantly decreased and were significantly lower than those in western medicine group（ P < 0. 05）. There were no statistical differences in 24-hour urinary protein quantity before and after treatment in either TCM or western medicine groups（ P > 0. 05）. Conclusion Jianpi Qinghua Formula combined with western medicine can improve renal function of CRF patients with spleen deficiency and dampness-heat syndrome

and its anti-micro-inflammation mechanism might be related with regulating the levels of CRP

IL-6 and AGEs.