Leigongteng（ Tripterygium wilfordii） is well recognized by Chinese and western medical societies for the effectiveness in the treatment of autoimmune diseases. However

acute or chronic multi-organ intoxication causes a constraint on its clinical application. This study performed a systematic combing through clinical and experimental studies on Leigongteng（ Tripterygium wilfordii） ’s detoxicity effect in compatibility

and proposed "Diversity Restriction" hypothesis including three aspects i. e. restricted by opposite properties and tastes

restricted by different efficacy and restricted by strengthening the body resistance.