Objective To observe the effect of combined treatment of Weifu Formula and chemotherapy on the quality of life in advanced gastric carcinoma patients with spleen deficiency and toxin accumulation syndrome.Methods In total 60 cases of advanced gastric cancer patients with spleen deficiency and toxin accumulation syndrome were randomly divide into a control group and a treatment group

with 30 cases in each. Both groups were treated with FOLFOX6 regimen

but the treatment group was added with Weifu Formula

a Chinese herbal decoction

one dose daily. 14-days was a treatment course

and both groups were observed for 2 courses. Changes in QLQ-C30 score

Piper fatigue scale（ PFS） score

TCM syndrome score

Karnofsky score

as well as gastrointestinal adverse effects and myelosuppression were observed. Results After treatment

the improvement of QLQ-C30 scores

PFS scores

TCM syndrome scores

and Karnofsky scores in the treatment group were better than those in the control group（ P < 0. 05）. Myelosuppression and gastrointestinal toxicity were milder in the treatment group than that in the control group

with significant differences（ P < 0. 05）. Conclusion Weifu Formula can improve the quality of life in advanced gastric carcinoma patients with spleen deficiency and toxin accumulation syndrome. It also helpful in alleviating myelosuppression and gastrointestinal adverse effects caused by chemotherapy.