Objective To observe the clinical efficacy and safety of Qingpeng Ointment（ QPRG） and Xinhuang Tablets（ XHP） combined with famciclovir tablets in treating herpes zoster neuralgia. Methods Totally 135 herpes zoster neuralgia patients were randomly assigned to QPRG group of 47 cases

XHP group of 43 cases and combined group of 45 cases. Each group took famciclovir tablets orally for 7 days. The QPRG group applied QPRG on pain area

twice per day. The XHP group took XHP orally

0. 96 g each time

3 times a day. The combined group applied both QPRG and XHP with the same methods as above. The course was 3 weeks for all groups. The visual analogue scales（ VAS） score

a secondary symptom（ the frequency of pain occurred daily

duration and dimensions） score and adverse effects were recorded before treatment and 1

2

3 weeks after treatment. Results The VAS scores and secondary symptom scores in each group decreased with the treatment undergoing

and differences were statistically significant between that before treatment and 1

2 and 3 weeks after treatment in each group（ P < 0. 01）. The VAS scores and secondary symptom scores of the combined group 1

2 and 3 weeks after treatment were lower than that of the QPRG group and XHP group（ P < 0. 05）. After two weeks of treatment the clinical efficacy in the combined group was better than those in these two groups（ P < 0. 05）. No statistically significant difference showed in adverse events’ occurrence among the groups（ P > 0. 05）. Conclusion The combined treatment of Qingpeng Ointment and Xinhuang Tablets with famciclovir tablets is safe and effective

with the advantages of quick onset

better efficacy and less adverse effects.