Objective To discuss the impact on renal toxicity with the compatibility of raw Chuanwu（ Aconitum carmichaelii

川乌） and raw Banxia（ Pinellia ternata

半夏） and its relation with different proportions. Methods Raw Chuanwu（ Aconitum carmichaelii

川乌） and raw Banxia（ Pinellia ternata

半夏） mixed lyophilized powders with the proportion of 1 ∶ 0

4 ∶ 1

2 ∶ 1

and 1 ∶ 1 were made. Fifty SD rats were randomly divided into control group

Chuanwu group

Chuanwu-4 Banxia-1 group

Chuanwu-2 Banxia-1 group

and Chuanwu-1 Banxia-1 group

with 10 in each. In addition to being given the same amount of Chuanwu（ 0. 8 g / kg）

each group was administered with the solution（ 4 ml / kg） of mixed lyophilized powder in the correspondence set proportion

and the control group received an equal volume of normal saline. Levels of microalbumin（ m Alb） and transferring（ TRF） in urine and blood urea nitrogen（ BUN）

serum creatinine（ SCr）

and β2-microglobulin（ β2-MG） were tested 24 h after last administration of 4 weeks gavage and 2 weeks after withdrawal. Renal index was calculated and morphology was observed. Results After 4 weeks of administration

levels of m Alb

TRF

BUN

SCr

and β2-MG in each treatment group were significantly higher than those in the control group（ P < 0. 05 or P < 0. 01）

except for the serum level of BUN in the Chuanwu-1 Banxia-1 group. The renal index in Chuanwu group

Chuanwu-4 Banxia-1 group

and Chuanwu-2Banxia-1 group were significantly higher than that the control group（ P < 0. 05 or P < 0. 01）. The above indicators in Chuanwu group were significantly higher than those in other treatment groups（ P < 0. 05 or P < 0. 01）

and there were no significant differences in indicators between the Chuanwu-2 Banxia-1 group and the Chuanwu-1 Banxia-1 group（ P > 0. 05）. Two weeks after drug withdrawal

there were no statistical differences in renal index

levels of m Alb

TRF

BUN

SCr

and β2-MG among groups（ P > 0. 05）. Conclusion Raw Chuanwu（ Aconitum carmichaelii

川乌） has obvious renal toxicity

but with the compatibility of different proportions of raw Banxia（ Pinellia ternata

半夏）

the toxicity is alleviated. Also

within a certain range

renal toxicity decreased with the proportion of raw Banxia（ Pinellia ternata

半夏） escalating.