Objective To observe the clinical efficacy of Jiuwei Zhenxin Granules in the treatment of post stroke anxiety disorder with heart and spleen deficiency syndrome. Methods In total 120 patients were randomly assigned to treatment group and control group

with 60 in each. The treatment group took Jiuwei Zhenxin Granules

6 g each time

three times daily

while the control group took citalopram tablets

20 mg each time

four times a day

for 6weeks. The scores of Hamilton Anxiety Scale（ HAMA）

Clinical Global Impression Scale（ CGI）

Chinese Stroke Neurological Deficit Scale（ CNS） were recorded before treatments and on week 1

2

4

and 6 after treatments to evaluate the safety and clinical efficacy. Results The total efficiency rates of the treatment group and control group were 80. 67% and 91. 67%

respectively

with no statistical significant difference（ P > 0. 05）. On week 4 and 6after treatments

scores of the HAMA and CGI were lower but CNS scores was higher in both groups compared with those before treatments（ P < 0. 05 or P < 0. 01）. After treatment

there was no significant difference in psychogenic anxiety scores between the two groups（ P > 0. 05）

but the somatic anxiety scores in the treatment group were significant lower than that in the control group（ P < 0. 05）. Conclusion Jiuwei Zhenxin Granules not only could improve the symptoms of post stroke patients with anxiety disorder and heart and spleen deficiency syndrome

but could help the recovery of neurological function and reduce the occurrence of adverse effects.