1. 广州中医药大学第一临床医学院
2. 广州中医药大学第一附属医院
3. 广东省中医药工程技术研究院
4. 广东省第二中医院
5. 广东省妇幼保健院
纸质出版:2015
移动端阅览
[1]李丽美,陶莉莉,孙冬梅,陈玉兴,陈小平,和秀魁.民间验方“姜醋”不同配比对产后缺乳模型大鼠泌乳的影响[J].中医杂志,2015,56(04):335-337.
LI Limei, TAO Lili, SUN Dongmei, et al. Effect of Different Ingredient Proportion in Jiang Cu on Lactation of Rat Models with Postpartum Hypogalactia[J]. Journal of Traditional Chinese Medicine2015, 56(4): 335-337.
[1]李丽美,陶莉莉,孙冬梅,陈玉兴,陈小平,和秀魁.民间验方“姜醋”不同配比对产后缺乳模型大鼠泌乳的影响[J].中医杂志,2015,56(04):335-337. DOI: 10.13288/j.11-2166/r.2015.04.018.
LI Limei, TAO Lili, SUN Dongmei, et al. Effect of Different Ingredient Proportion in Jiang Cu on Lactation of Rat Models with Postpartum Hypogalactia[J]. Journal of Traditional Chinese Medicine2015, 56(4): 335-337. DOI: 10.13288/j.11-2166/r.2015.04.018.
目的观察不同配比的"姜醋"对产后缺乳大鼠模型的作用
寻找"姜醋"的合理配比。方法将96只产后第1天的母鼠随机分成空白对照组、模型对照组、通乳颗粒组和姜醋1-9号组
每组8只
每只母鼠下分配8只仔鼠。除空白组对照外
各组大鼠采用左旋多巴腹腔注射诱发产后缺乳大鼠模型。空白对照组与模型对照组不干预;通乳颗粒组给予8.1 g/(kg·d)通乳颗粒;姜醋1-9号组按L9(38)正交表给予不同比例原材料制备的"姜醋"13.5 g/(kg·d)。连续给药10天。检测各组母鼠血清中催乳素(PRL)的含量
记录各组仔鼠第5、10天的体重增加值
计算第10天仔重增加率和母鼠PRL含量的提高率。结果姜醋1-9号组与通乳颗粒组第5天仔鼠重增长值较模型对照组明显增加(P<0.01);姜醋2、5、6、7、9号组与通乳颗粒组第10天仔鼠重增长值较模型对照组明显增加(P<0.05或P<0.01)。模型对照组母鼠PRL水平较空白对照组明显降低(P<0.01);姜醋2、3、5、6、7、9号组与通乳颗粒组母鼠PRL水平较模型对照组明显增加(P<0.01)。结论 "姜醋"能增加左旋多巴所致缺乳母鼠PRL水平及仔鼠体重
其中以生姜1000 g、鸡蛋12个、醋250 g、猪蹄2个配比的"姜醋"作用效果最好。
Objective To observe the efficacy of different proportions of ingredients in Jiang Cu( JC) on postpartum hypogalactia rats so as to find a superior proportion. Methods Totally 96 female rats one day postpartum were randomly divided into control group
model group
Tongru Granules group and JC 1 to 9 groups
with 8 rats in each. Meanwhile 8 newborn baby rats were given for each female rat. Except for the control group
every group was injected with levodopa to induce the model of postpartum hypogalactia. No intervention was used on the control group and model group. The Tongru Granules group were given Tongru Granules( 8. 1 g / kg); JC 1- 9 groups were given JC( 13. 5 g /kg) with different proportions according to L9( 38) orthogonal table
all for 10 days. The serum levels of prolactin( PRL) were tested and the weight gains of baby rats were recorded on day 5 and day 10. Then the weight increasing rates and PRL increase rate were calculated on day 10. Results On day 5
the weight gains of baby rats in JC 1- 9 group and Tongru Granules group were significantly more than that in the model group( P < 0. 01); On day10
the weight gains of baby rats in JC 2
5
6
7
9 groups and Tongru Granules group were significantly more than that in the model group( P < 0. 05 or P < 0. 01). The PRL levels in the model group were significantly lower than that in the control group( P < 0. 01); the PRL levels in the JC 2
3
5
6
7
9 groups and Tongru Granules group were significantly higher than that in the model group( P < 0. 01). Conclusion JC could increase the PRL levels of hypogalactia rats induced by levodopa and weight gain of baby rats. Best effect can be achieved when the proportion in JC is 1000 g of ginger
12 eggs
250 g of vinegar
and 2 pettitoes.
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