Objective To conclude the prescription patterns of Chinese medicine compounds（ CMC） in the treatment of leukopenia based on literature. Methods All clinical researches on treating leukopenia with internal CMC were retrieved from Chinese Biological and Medical Database

Chinese Journal Full-text Database

Wanfang Database and VIP Database. The relevant information was extracted to establish a data table to calculate the frequency of usage

categories

properties

tastes and channel tropism of the Chinese medicines prescribed. Results In total132 articles were included

involving 132 prescriptions with an average of 11 Chinese medicines in each and 118 Chinese medicines with the frequency of use of 1417. The top 11 medicines with the highest frequency of use were Huangqi [Astragalus membranaceus（ Fisch.） Bunge.

黄芪]

Danggui [Angelica sinensis（ Oliv.） Diels

当归]

Jixueteng（ Kadsura interior

鸡血藤）

Baizhu（ Atractylodes macrocephala

白术）

Cooked Dihuang（ Rehmannia glutinosa

熟地黄）

Gancao（ Radix Glycyrrhizae

甘草）

Nvzhenzi（ Ligustrum lucidum Ait.

女贞子）

Gouqizi（ Lycium barbarum L.

枸杞子）

Dangshen [Codonopsis pilosula（ Franch.） Nannf.

党参]

Buguzhi（ Psoralea corylifolia Linn.

补骨脂） and Fuling [Poria cocos（ Schw.） Wolf

茯苓]

with the cumulative frequency of 758. In the 16 categories involved

the top three mostly used were tonifying（ 1003 times）

invigorating blood circulation and removing blood stasis（ 123 times） and clearing dampness by promoting diuresis（ 63 times）. The top 3 mostly used properties were warm（ 743 times）

gentle（ 419 times） and cold（ 165 times）. As for tastes

the top 3 were sweet（ 1152 times）

bitter（ 480 times） and spicy（ 319 times）

and for channel tropism

the top 3 were the Spleen Meridian（ 850 times）

the Liver Meridian（ 692 times） and the Kidney Meridian（ 673 times）. Conclusion The most popular CMC for leukopenia were mainly with the effects of tonifying qi and nourishing blood

warming kidney and strengthening spleen

as well as invigorating blood circulation to removing blood stasis and clearing heat and detoxification

with Huangqi and Danggui as the core medicines.