With the deep study of the incompatibility of medicinals represented by "the eighteen antagonisms"

the understanding of the connotation and toxic-effect of the incompatibility of Chinese medicinals reaches a new level

especially in a typical inverse relationship which may involve toxication

increasing toxicity

reducing the efficiency

reflecting the seven kinds of complex relations between the opposites. This paper plays an important role to investigate the historical evolution of incompatibility of Chinese medicinals and the resulting harms of inter-antagonizing medicinals

especially the potential harms of incompatibility. It also explains its origin and development

analyze the characteristic multi-dimension potential harm

the tradeoff of potential harm and drawing on the advantages and avoiding disadvantages in "the eighteen antagonisms"mechanism

as well as the theoretical innovation of Chinese medicinal incompatibility.