1. 中国中医科学院西苑医院
2. 首都医科大学附属北京同仁医院
纸质出版:2015
移动端阅览
[1]蒋跃绒,谢元华,张京春,史大卓.陈可冀治疗心血管疾病血瘀证用药规律数据挖掘[J].中医杂志,2015,56(05):376-380.
JIANG Yuerong, XIE Yuanhua, ZHANG Jingchun, et al. CHEN Keji’s Medication Laws for Treating Blood Stasis Pattern of Cardiovascular Diseases: A Data Mining Research[J]. Journal of Traditional Chinese Medicine2015, 56(5): 376-380.
[1]蒋跃绒,谢元华,张京春,史大卓.陈可冀治疗心血管疾病血瘀证用药规律数据挖掘[J].中医杂志,2015,56(05):376-380. DOI: 10.13288/j.11-2166/r.2015.05.005.
JIANG Yuerong, XIE Yuanhua, ZHANG Jingchun, et al. CHEN Keji’s Medication Laws for Treating Blood Stasis Pattern of Cardiovascular Diseases: A Data Mining Research[J]. Journal of Traditional Chinese Medicine2015, 56(5): 376-380. DOI: 10.13288/j.11-2166/r.2015.05.005.
目的总结陈可冀院士治疗心血管病血瘀证的用药规律。方法采集经陈可冀院士诊治且资料完整的心血管疾病血瘀证患者医案277份
建立医案数据库
记录患者一般资料、初诊记录、理化检查、中药处方、复诊记录。统计活血化瘀药物使用频次
采用关联规则对药物配伍、药-病、药-症关系进行对应分析
并对症状、体征的常用药物进行多维数据分析。结果心血管疾病血瘀证治疗共使用活血化瘀药20种
其中使用频次排在前5位的依次为赤芍(32.13%)、延胡索(29.60%)、川芎(28.88%)、丹参(25.99%)、红花(23.10%)。药-病关联分析显示
冠心病支架置入术后血瘀证常用川芎、赤芍;高血压病血瘀证常用牛膝、赤芍、生地黄、川芎、丹参;心律失常血瘀证常用延胡索、川芎、生地黄、丹参、当归。冠心病出现心痛症状时
使用药物置信度最高的是延胡索(0.80)、丹参(0.80)、薤白(0.80)
出现紫暗舌、黄苔时
置信度最高的是赤芍(0.80)
紫暗舌、畏寒同时出现时
置信度最高的是当归(1.00);多维数据分析显示
血瘀证不同症状、体征用药也有差别
治疗瘀斑舌牡丹皮使用较多
治疗心痛延胡索使用较多
治疗头痛川芎使用较多。结论陈可冀院士治疗心血管病血瘀证常用赤芍、延胡索、川芎
临证根据疾病、病位、兼证和兼症的不同
灵活选用活血化瘀药。
Objective To analyze the medication laws for blood stasis pattern of cardiovascular diseases treated by Academician CHEN Keji. Methods Medical cases with complete data recording Academician CHEN’ s treatment were collected and the database was established to pool general information
first visit to doctor
physical and chemical inspection
prescriptions of traditional Chinese medicine and further consultation. The medicinals for promoting invigorating blood circulation and eliminating stasis were calculated
and the correspondence of medicinalsmedicinals
medicinals-diseases
and medicinals-symptoms were analyzed
with assocation rules
and frequently used medicinal geared to symptoms and physical signs were treated by multidimensional data analysis. Results A total of 20 medicinals on activating blood and eliminating stasis were used for cardiovascular diseases with blood stasis syndrome( BSS). The top 5 frequently-used medicinals were Chishao( Radix Paeoniae Rubra
32. 13%)
Yanhusuo( Rhizoma Corydalis
29. 60%)
Chuanxiong( Ligusticum Chuanxiong
28. 88%)
Danshen( Salvia Miltiorrhiza
25. 99%) and Honghua( Safflower Carthamus
23. 10%). Association analysis between medicinals and diseases showed that Chuanxiong( Ligusticum Chuanxiong) and Chishao( Radix Paeoniae Rubra) had the highest confidence coefficient( CC) for post-Stenting coronary heart disease patients with blood-stasis pattern. The most frequently used medicinals for hypertension patients with BSS were Niuxi( Achyranthes bidentata)
Chishao( Radix Paeoniae Rubra)
Gandihuang( dried Rehmannia)
Chuanxiong( Ligusticum Chuanxiong) and Danshen( Salvia Miltiorrhiza).The most frequently used medicinals for arrhythmia patients with BSS were Yanhusuo( Rhizoma Corydalis)
Chuanxiong( Ligusticum Chuanxiong)
Gandihuang( dried rehmannia)
Danshen( Salvia Miltiorrhiza) and Danggui( Angelica sinensis). Yanhusuo( Rhizoma Corydalis
0. 80)
Danshen( Salvia Miltiorrhiza
0. 80) and Xiebai( Allium macrostemon Bunge
0. 80) had the highest CC when cardiovascular diseases presented with cardiac pain. While the CC of Chishao( Radix Paeoniae Rubra) was 0. 80 when purple dark tongue with yellow coating occurred. When purple dark tongue accompanied with intolerance of cold
the CC of Danggui( Angelica sinensis
1. 00) was the highest. Multidimensional data analysis showed that the medication differed when BSS presented with different symptoms and signs
Mudanpi( Cortex Moutan Radicis) always be selected to treat ecchymosis tongue
Yanhusuo( Rhizoma Corydalis) treat cardiac pain and Chuanxiong( Ligusticum Chuanxiong) to treat headache.Conclusion The analysis results were consistent with the characteristics of Academician CHEN’ s selecting medicinals in treating cardiovascular diseases according to the differences in disease type
disease location
and accompanied syndromes and symptoms.
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