Objective To observe the influence of adjusted Wenyang Yiqi Huoxue Formula（ WYYQHXF） on intestinal flora and lipid metabolism of obese type 2 diabetic patients. Methods Totally 98 obese type 2 diabetic patients were randomly assigned to a treatment group and a control group

each group of 49 cases. The control group received basic treatment and Metformin Hydrochloride Tablets

250 mg three times a day

while on the basis of that

the treatment group received adjusted WYYQHXF orally

one dose daily

both groups were treated for 2 months.Before and after treatments

the TCM symptom scores

fasting insulin（ FINS）

fasting plasma glucose（ FPG）

insulin resistance index（ HOMA-IR）

serum lipids and changes of the intestinal flora were observed. Results The symptom effective rate of the treatment group and the control group was 93. 88% and 71. 43% respectively

the difference between groups was significant（ P < 0. 05）. After the treatments

the symptom scores of both groups improved significantly（ P < 0. 05）; FINS and HOMA-IR of the treatment group decreased notedly; indexes of lipid metabolism improved significantly; the number of Bifidobacterium

Bacteroides and Lactobacillus notedly increased

with the number of Enterobacter

Enterococcus and yeast significantly reduced（ P < 0. 05）. The symptom scores

FINS

HOMA-IR

total cholesterol

triglyceride

low density lipoprotein cholesterol and the number of Enterobacter

Enterococcus and yeast of the treatment group were significantly lower than those of the control group

while high density lipoprotein cholesterol and the number of Bifidobacterium

Bacteroides and Lactobacillus were significantly higher than those of the control group（ P < 0. 05）. Conclusion Adjusted WYYQHXF could significantly improve the symptoms and lipid metabolism of obese type 2 diabetic patients

rebalancing their intestinal flora.