Objective To explore the relationship between different types of thalassemia（ α-thalassemia

β-thalassemia

complex thalassemia） with the scores of kidney deficiency syndromes and genotypes（ homozygotes

heterozygotes）. Methods Clinical data of thalassemia patients were collected

including age

gender

height

weight

nation

type of thalassemia

genotype and 26 kidney deficiency related symptoms and signs. Different genotypes

the constituent ratio of TCM kidney deficiency symptoms and signs and kidney deficiency syndrome scores of different thalassemia types were analyzed. Results A total of 299 thalassemia patients with kidney deficiency syndrome were included

with 201 cases of α-thalassemia

86 cases of β-thalassemia and 12 cases of complex thalassemia. SEA / αCSα was most commonly found in α-thalassemia genotypes

while β41- 42 in β-thalassemia homozygous genotype and β41- 42/ βEin heterozygous genotype. In the 287 uncomplex thalassemia

189 patients（ 65. 85%） had kidney-yin deficiency

followed by 85 kidney-essence deficiency（ 29. 62%） and 13 kidney-yang deficiency（ 4. 53%）. The constituent ratio of three kidney deficiency types indicated statistical significance（ P = 0. 020）. In these patients

pale yellow complexion

sweating during sleep

pale lips

lassitude

dry throat and dry mouth were the most common symptoms and signs among the 26 related symptoms. The constituent ratio of kidney deficiency related symptoms and signs of different thalassemia types showed no statistical significance（ P > 0. 05）. Conclusion Though with different genotypes

all types of thalassemia showed kidney deficiency syndrome and kidney-yin deficiency was most commonly seen

with pale yellow complexion

sweating during sleep

pale lips

lassitude

dry throat and dry mouth as the main clinical manifestations.