The traditional Chinese medicine（ TCM） pathological mechanism of type 2 diabetes is that phlegm turbidity and blood stasis generated on the basis of spleen and stomach deficiency. Spleen and stomach deficiency is the root cause

and phlegm and static blood binding together is the branch cause. It is closely related to nutrient pathway. And its pathogenesis process is consistent with the activation mechanism of nutrient pathway. Therefore

to improve nutrient pathway becomes a new therapeutic strategy for insulin resistance and other related diseases. The following limitations exist in recent insulin resistance studies: selection of indicators does not reflect the combination of disease and syndrome; animal models of TCM syndrome in insulin resistance are not enough; and there are few large samples

multi-center

randomly controlled studies in clinical research. To solve these problems

this paper proposes that the future study should be carried out from two respects（ clinical and animal experiments）

three levels（ animals

cell

and molecules）

and two perspectives（ macro and micro）. The pathogenesis of insulin resistance in type2 diabetes should be deeply studied through observing changes in nutrient pathway.