Objective To evaluate the clinical effect of Honghe Jiaonang on multi-drug-resistant tuberculosis（ MDR-TB） of Yin deficiency

lung heat and collateral injury pattern. Methods Totally 128 patients of MDR-TB of Yin deficiency

lung heat and collateral injury type were randomly divided into treatment group and control group with 64 cases of each group. The control group was given western chemotherapy regimen

3DL1 OZA /18DL1 OZ

for12 months

the treatment group was given Honghe Jiaonang（ Formula Concentrate-granules）

one dose each day

for6 months. Compare therapeutic effect of traditional Chinese medicine（ TCM） syndrome and X-ray

sputum negative conversion rate

immunological indexes and adverse reactions. Results Comparing improvement in TCM syndrome

the treatment group was superior to the control group（ P < 0. 05）. For the therapeutic effect of X-ray

focus absorption rate of both group increased with treating time going on. Difference of adjacent time point within each group was significant（ P < 0. 05 or P < 0. 01）; after 6 and 9 months

indexes of treatment group were obviously better than that of control group（ P < 0. 05）. Sputum negative conversion rate of both groups increased with treating time increasing. Difference of adjacent time point within group was significant（ P < 0. 05）. When treating for 3

6

9 and 12 months

treatment group was superior to control group（ P < 0. 05）. CD3+

CD4+and interleukin-17 of both groups increased evidently after treatment（ P < 0. 05 or P < 0. 01）. All indexes of the treatment group were superior to that of the control group（ P < 0. 05）. Abnormality of blood

urine and stool routine

renal function and electrocardiogram was not found before and after treatment. Comparing alanine aminotransferase（ ALT） and gastrointestinal reaction

there was no statistical significance between two groups（ P > 0. 05）. Conclusion Treating MDR-TB of Yin deficiency

lung heat and collateral injury type

Honghe Jiaonang could improve clinical effect and possess good safety.