Objective To observe therapeutic effect and security of tonifying kidney and invigorating blood method to treat senile osteoporosis. Methods Totally 200 senile osteoporosis patients were randomized into treatment group and control group

with 100 patients in each group. The treatment group took traditional Chinese medicine of tonifying kidney and invigorating blood

one dose daily. The control group took alendronate sodium 70 mg

once a week

and calcium carbonate D3 tablets 600 mg

once per day. Two groups were treated for 24 weeks. Scores of syndrome

bone mineral density（ BMD） of lumbar vertebra（ L1- L4）

BMD of left collum femoris

serum osteocalcin（ BGP）

bone alkaline phosphatase（ BAP）

I tropocollagen N-propeptide（ PINP）

tartrate-resistant acid phosphatase（ TRACP-5b）

I collagen cross-linking C-peptide（ CTX） and security index before and after treatment were compared between the two groups. Finally

the researchers evaluated the curative effect of Chinese medical syndrome after treatment. Results The treatment group had 92% curative effect of Chinese medical syndrome

significant higher than that of the control group（ 79%

P < 0. 05）. Score of syndrome

BMD of lumbar vertebra and collum femoris

BGP

BAP

TRACP-5b

PINP

CTX improved significantly after treatment in both groups（ P < 0. 01）. After treatment the treatment group’s score of syndrome

BMD of lumbar vertebra and collum femoris

BGP

BAP were superior to the control group（ P < 0. 05）. No abnormal change of security index was found in both groups. Conclusion Tonifying kidney and invigorating blood may effectively enhance BMD in senile osteoporosis patients

and improve clinical symptoms. These effects may be related to effective regulation of metabolic balance of bone turnover.