Objective To observe the clinical effect and safety of Jieyu Jiaonang combined with paroxetine tablets on depression. Methods Totally 100 depression patients were randomly divided into treatment group and control group with 50 cases in each group. At last

there were respectively 49 cases accomplished the trial in both groups. Treatment group was given Jieyu Jiaonang 4 capsules each time

3 times each day and paroxetine tablets 20 mg each time

1 time each day orally

and the control group was given paroxetine tablets only

for 6 weeks. Compare Hamilton Depression Scale（ HAMD）

Hamilton Anxiety Scale（ HAMA）

Clinical Global Impression Scale（ CGI）including severity of illness（ SI）

global improvement（ GI） and efficacy index（ EI）

clinical effect and adverse reactions. Results After 2

4

6 weeks

total scores of HAMD

HAMA and SI in both groups decreased obviously（ P < 0. 01）. Total scores of HAMD

GI and EI of treatment group were lower than those of control group at the same time point（ P < 0. 05 or P < 0. 01）. Total scores of HAMA and SI of treatment group were lower than that of control group at the same time point（ 2nd

6th week

P < 0. 05 or P < 0. 01）. After treatment

all factors’ scores in HAMD of both groups decreased significantly at different time（ P < 0. 05 or P < 0. 01）. After 2 weeks

factors’ scores of anxiety

weight

sleep disorder and despair of treatment group were lower than that of control group（ P < 0. 05 or P <0. 01）. After 4 weeks

the factor score of feeling in morning or evening was lower than that of control group（ P <0. 01）. After 6 weeks

factors’ scores of anxiety

cognition

retardation and despair were lower than that of control group（ P < 0. 05 or P < 0. 01）. The clinical effect of treatment group was superior to control group（ P < 0. 01）.Conclusion Jieyu Jiaonang combined with paroxetine tablets could improve clinical effect in depression

with less adverse reactions than Western medicine alone.