Objective To observe the effect and safety of oral herbal decoction which could supplement Qi

nourish Yin

promote blood circulation and induce diuresis combined with intravitreal injection of triamcinolone acetonide（ TA） treating non-proliferative diabetic retinopathy（ NPDR） diffuse macular edema（ DME）. Methods Sixty patients（92 eyes） with NPDR DME were randomly divided into treatment group（ 30 cases

47 eyes） and control group（ 30 cases

45 eyes）. On the first day of treatment

patients of both groups were given intravitreal injection of 4 mg TA. The treatment group was added oral herbal decoction which could supplement Qi

nourish Yin

promote blood circulation and induce dieresis

one dose every day

for 3 months. Observe the visual acuity of affected eyes

retinal thickness and macular leakage before treatment and 3 and 6 months after injection. Measured intraocular pressure

anterior and posterior segment on the 1st

3rd

7th day

3 months and 6 months after injection. Results Three months and six months after injection

the effective rate of treatment group was 89. 36% and 87. 23% respectively

while that of the control group was 73. 33% and 62. 22% respectively（ P < 0. 05 or P < 0. 01）

and the visual acuity and retinal thickness of treatment group were improved significantly

the improvement of the treatment group was superior to that of the control（ P < 0. 05 or P < 0. 01）. There was no remarkable side effect in treatment group. There was 1 case of pan bottom opacity under lens posterior capsule in control group at 6 months after injection

which influenced visual acuity severely. Conclusion Oral herbal decoction which could supplement Qi

nourish Yin

promote blood circulation and induce diuresis combined with intravitreal injection of TA treating NPDR DME could improve patients’ visual acuity and relieve retinal edema and macular leakage. The effect was stable and the therapy seems safe.