Objective To observe the clinical effect of mid-summer and mid-winter point application on chronic obstruction pulmonary diseases（ COPD）. Methods Totally 160 COPD patients were randomly divided into treatment group and control group

80 cases in each group. Both groups were given ambroxol hydrochloride orally

30 mg each time

3 times each day and other symptomatic treatment. Treatment group was additionally given application therapy. Baijiezi（ Semen brassicae）

mahuang（ Ephdra sinica stapf）

kuxingren（ Semen armeniacae amarae）

yangjinhua（ Flos daturae）

gansui（ Euphorbia kansui）

yanhusuo（ Corydalis ambigua Ch.） and xixin（ Asarum sieboldi Mig.） were powdered to make a paste using ginger juice and fixiform. Control group was given application of placebo. The placebo cakes were made of ginger juice and excipient. Both groups were given application therapy on Tiantu（ RN22）

Danzhong（ RN17） and Feishu（ BL13）（ bilateral） on the first day of first

second

third dog-day and first

second third nine-day after winter solstice for 3 years. Test FEV1% pred

Ig A

Ig G

Ig M and Ig E at every September and meanwhile follow up and record cough

phlegm

chest tightness and short breath on COPD acute attack one year before and after treatment and attack times

duration and catching cold times. Compare records of 3 years.Record cardinal symptom score and side effect of patients in both groups and evaluate symptom effect. Results Compared with control group

after 3 years of application treatment

symptoms such as cough

phlegm

chest tightness and short breath of treatment group patients were relieved during acute attack（ P < 0. 01）. Every year catching cold times

attack times and duration decreased（ P < 0. 01）. FEV1% pred

Ig A

Ig G and Ig M increased（ P < 0. 01）.Ig E decreased（ P < 0. 01）. Compare in treatment group

as time of application treatment lasted

cough

phlegm

chest tightness and short breath during acute attack were relieved year by year. Catching cold times

attack times and duration decreased every year. FEV1% pred

Ig A

Ig G and Ig M increased and Ig E decreased year by year. Symptom effect of treatment group on 1st

2nd and 3rd year was 56. 6%

86. 0% and 93. 4%

which was significantly higher than that of control group 11. 4%

13. 7% and 20. 1%（ P < 0. 01）. Effect of treatment group was increased year by year（ P < 0. 01）. There was no severe side effect during treatment in both groups. Conclusion Mid-summer and mid-winter point application treating COPD was effective

it could improve pulmonary function and immunity.