Objective To observe the clinical efficacy of Yishen Gukang Fang（ YGF） combined with hyperthermia auxiliary with western medicine on painful bone metastatic cancer. Methods A multicenter randomized controlled study was conducted

and 182 patients with painful bone metastatic cancer were recruited from three research centers.The patients were randomly divided into a treatment group with 90 cases and a control group with 92 cases. Both groups were given oral Oxycodone & Acetaminophen tablets

one tablet per time

once every 6 hours. The dose could be adjusted according to the pain degrees. The treatment group was added with YGF one agent daily and radiofrequency hyperthermia on the pain locations twice per week. After treatments for 14 days

the clinical efficacies in the two groups were observed. The scores of Physical condition and pain effects（ including daily activities

emotions

walking ability

proper functioning

relationship with others

sleeping

and amenity of life） were evaluated before and after treatments. Results The total effective rate of clinical efficacy was 77. 8% in the treatment group

and 53. 3% in the control group. The treatment group was significantly superior to the control group（ P < 0. 01）. In the treatment group

the pain effects scores of daily activities

emotions

sleeping

and amenity of life were obviously lower after treatments（ P < 0. 01）

and also lower than that in the control group after treatment（ P < 0. 05 or P < 0. 01）. The Physical condition stable increase rate was 95. 6% in the treatment group

and 88. 0% in the control group. The treatment group was much superior to the control group（ P < 0. 05）. Conclusion YGF combined with hyperthermia auxiliary with western medicine shows better analgesics and improving clinical symptoms functions than single western medicine treatment on patients with painful bone metastatic cancer.