Objective To explore the distribution and evolution rule of syndrome elements on different stages of bronchial asthma. Methods Bronchial asthma patients in 16 TCM hospitals were included. Make clinical questionnaire of bronchial asthma

and collect demographic data and Traditonal Chinese medicine（ TCM） syndrome of patients. Extract syndrome elements from syndrome differentiation results and establish data base. Make statistics of patients’ syndrome elements distribution of nature and location of disease on acute attack

chronic persistent stage and clinical remission respectively. Compare constituent ratio of all syndrome elements on different stages. Results There were 2500 questionnaires given out

2481 taken back and 2428 valid. Extract 11 syndrome elements of disease nature from 1273 patients on acute attack. Total frequency was 2902. Top three syndrome elements were phlegm（ 54. 12%）

cold（ 42. 11%） and fluid（ 42. 11%）. Extract 6 syndrome elements of disease location. Total frequency was 1304. Top three location were lung（ 71. 09%）

spleen（ 14. 06%） and kidney（ 8. 09%）. Extract 11 syndrome elements of disease nature from 586 patients on chronic persistent stage. Total frequency was 1407. Top three were Qi deficiency（ 59. 73%）

phlegm（ 42. 32%） and cold（ 42. 32%）. Extract 6 syndrome elements of disease location.Total frequency was 998. Top three were lung（ 89. 08%）

spleen（ 41. 98%） and kidney（ 30. 72%）. Extract 10 syndrome elements of disease nature from 569 patients on clinical remission. Total frequency was 843. Top three were Qi deficiency（ 72. 58%）

Yang deficiency（ 16. 70%） and Yin deficiency（ 13. 88%）. Extract 5 syndrome elements of disease location. Total frequency was 833. The top three were lung（ 70. 65%）

spleen（ 40. 42%） and kidney（ 29. 53%）. Compared to acute attack

about syndrome elements of disease nature

constituent ratio of heat decreased and that of Qi deficiency increased on chronic persistent stage; about syndrome elements of disease location

constituent ratio of spleen and kidney increased（ P < 0. 05 or P < 0. 01）. Compared to acute attack

about syndrome elements of disease nature

constituent ratio of phlegm

cold

fluid and heat decreased and that of Qi and Yang deficiency increased on clinical remission; about syndrome elements of disease location

constituent ratio of spleen and kidney increased（ P < 0. 05 or P < 0. 01）. Compared to chronic persistent stage

about syndrome elements of disease nature

constituent ratio of phlegm and cold decreased and that of Qi deficiency increased on clinical remission（ P < 0. 05 or P < 0. 01）. Conclusion Syndrome elements of disease nature on acute attack of bronchial asthma were mainly phlegm

cold

fluid and heat; disease location was mainly lung. On chronic persistent stage

syndrome elements of disease nature were mainly phlegm

cold and Qi deficiency; disease locations were mainly lung

spleen and kidney. On clinical remission

syndrome elements of disease nature were mainly Qi and Yang deficiency;disease locations were mainly lung

spleen and kidney. Blood stasis ran through the whole course.