Objective To observe the clinical effects of spleen-invigorating and kidney-soothing prescription combined with acupuncture on 34 cases of obesity-related glomerulopathy. Methods Totally 68 cases obesity-related glomerulopathy were divided into treatment group and control group randomly

with 34 cases in each. Both groups were given lifestyle intervention

appropriate exercise

diet control

and 150 mg of Irbesartan Tablets once daily;Treatment group was added with spleen-invigorating and kidney-soothing prescription orally one dose daily

and acupuncture treatment 30 min each time

once each day. Clinical effects on patients in both groups were evaluated after treatment for 9 weeks

and 24-hour proteinuria

levels of triglyceride（ TG）

total cholesterol（ TC）

high-density lipoprotein cholesterol（ HDL-C）

low density lipoprotein cholesterol（ LDL-C）

hemodynamic indexes（ including whole blood high sheathed viscosity

whole blood low sheathed viscosity

plasma high viscosity

fibrinogen

and hematokrit） were examined before and after treatment. Results Two cases dropped off in each group during the trial

so 32 cases in each group were observed completely. Total clinical effective rate was 90. 63% in treatment group and 62. 50% in control group

with significant difference between the two groups（ P < 0. 05）. Levels of 24-hour proteinuria

TG、TC、LDL-C and every index of hemodynamic all remarkably decreased but HDL-C increased in both group after treatment（ P < 0. 05）

especially in treatment group（ P < 0. 05）. Conclusion Spleen-invigorating and kidney-soothing prescription combined with acupuncture treatment can decrease urinary albumin excretion and blood lipid level and regulate the high blood coagulating state in patients suffering from obesity-related glomerulopathy with a definite curative effect.