Objective To investigate the correlations between resistin

leptin

adiponectin and liver stagnation and spleen deficiency syndrome in type 2 diabetic patients. Methods Fifty-nine cases of type 2 diabetic patients were grouped into liver stagnation and spleen deficiency group of 29 cases and non liver stagnation and spleen deficiency syndrome group of 30 cases according to TCM syndrome differentiation standard

and a normal control group of 28 cases was set also. The clinical data of each group was collected

including height

weight

abdominal circumference

body mass index（ BMI） was calculated

fasting blood glucose（ FBG）

postprandial 2H plasma glucose（ 2h PG）

glycosylated hemoglobin（ Hb Alc）

serum fasting insulin（ FINS）

postprandial 2H insulin level（ 2h PINS）

insulin resistance index（ HOMA-IR）

resistin

leptin and adiponectin level were tested. Correlation analysis between the indicators is analyzed by Pearson method. Results Compared with the normal control group

BMI

abdominal circumference

resistin and leptin levels were significantly increased

and adiponectin levels decreased significantly（ P < 0. 05 or P < 0. 01） in liver stagnation and spleen deficiency group and non liver stagnation and spleen deficiency group. Serum leptin levels of patients in liver stagnation and spleen deficiency group is higher than that in the non-liver stagnation and spleen deficiency group

however the adiponectin level is lower than that in the non-liver stagnation and spleen deficiency group（ P < 0. 05）. Compared with the non-liver stagnation and spleen deficiency group

FINS

HOMA-IR difference in liver stagnation and spleen deficiency group was statistically significant（ P < 0. 05）. Correlation analysis showed that leptin and resistin was positively related

leptin and adiponectin was negatively correlated

resistin was negatively correlated with adiponectin

which were statistically significant（ P <0. 05）. Conclusion Type 2 diabetic patients with syndrome of liver stagnation and spleen deficiency seems related with high leptin and low adiponectin.