Objective To investigate the possible mechanism of acupoint application in treating bronchial asthma. Methods Fifty patients with lung qi deficient bronchial asthma received acupoint application in dog days.One treatment was given in a dog day

altogether three times. Fifty healthy volunteers were enrolled as control group.The concentrations of serum immunoglobin E（ Ig E）

interferon-γ（ IFN-γ） and plasma P substance（ SP） before and after treatment were detected in both control and asthma group. The correlations of Ig E

IFN-γ and SP before and after treatment in patients with asthma were analyzed using Pearson correlation analysis. Results Before the treatment

concentrations of serum Ig E

IFN-γ and plasma SP in patients with asthma had statistical differences with those in control（ P < 0. 05）. Concentrations of serum Ig E

IFN-γ and plasma SP in patients with asthma before and after treatment were significantly different（ P < 0. 05）. Ig E was positively correlated with SP and negatively correlated with IFN-γ in patients with asthma before treatment（ P < 0. 05）. However

there was no relationship between SP and IFN-γ（ P > 0. 05）. There were also no significant relationships between Ig E

IFN-γ and SP after treatment（ P > 0. 05）.Conclusion Acupoint application based on winter disease treated in summer can improve immune function by regulating secretion of cytokine and release of neurotransmitter

leading to therapeutic effect in bronchial asthma.