Objective To observe the clinical efficacy of oral administration of traditional Chinese medicine Jianpi Qingchang Decoction（ 健脾清肠汤） combined with retention enema with Yushang Guanchang Decoction（ 愈疡灌肠方）in the treatment of chronic persistent ulcerative colitis with the spleen deficiency and dampness heat syndrome.Methods A total of 62 cases of chronic persistent ulcerative colitis with the spleen deficiency and dampness heat syndrome were randomly divided into treatment group and control group

with 31 cases in each group. The treatment group was given oral administration of Jianpi Qingchang Decoction combined with retention enema with Yushang Guanchang Decoction; The control group was given orally mesalazin enteric-coated tablets 1g each time

4 times a week.After 12 weeks of continuous treatment

the main symptom score and Baron endoscopic score of endoscopic examination of the colon mucosa in both groups were got to evaluate the clinical efficacy

and the adverse reactions were observed. Results The total effective rate was 93. 55% in the treatment group and 83. 87% in the control group

the treatment group was better than the control group（ P < 0. 05）. After treatment

the abdominal pain

diarrhea and bloody purulent stool integral and Baron endoscopic score in both groups were significantly decreased than those before the treatment（ P < 0. 01）; The scores of abdominal pain

diarrhea integral and Baron endoscopic score in the treatment group were significantly lower than those in the control group（ P < 0. 05）. No adverse reactions occurred in the treatment group

there were 3 cases of adverse reactions in the control group. Conclusion Oral administration of traditional Chinese medicine Jianpi Qingchang Decoction combined with retention enema with Yushang Guanchang Decoction in the treatment of chronic persistent ulcerative colitis with the spleen deficiency and dampness heat syndrome do have curative effect

it can improve the main clinical symptoms of patients

such as abdominal pain

diarrhea

bloody purulent stool and so on

it can promote the healing of intestinal mucosa of patients

and there is no obvious adverse reaction.