Objective To discuss the impact of Banxia Xiexin Tang on insulin resistance in diabetic gastric paralysis rats and the possible mechanism. Methods Totally 120 rats were randomly divided into blank group（ n =10） and DM modeled group（ n = 110）. In DM model group

DM models were established by intraperitoneal injection of streptozotocin（ 40 mg / kg）. Sixty successfully modeled rats were randomly divided into model group

metformin group（ 0. 3 g / kg）

domperidone group（ 0. 005 g / kg）

Banxia Xiexin Tang high dose group（ 1. 7 g / kg）

middle dose group（ 0. 85 g / kg） and low dose group（ 0. 425 g / kg）

10 rats in each group

by gavage continuously for 1week. Detected gastric residual rate

alvine pushing rate

content of motilin（ MOT）

vasoactive peptide（ VIP）

somatostatin（ SS） and substance P（ SP） in gastric antrum

fasting blood glucose（ FGB）

serum insulin（ FINS） and insulin resistance index（ IRI）. Results Comparing with blank group

gastric residual rate

alvine pushing rate

content of VIP

SS

MOT and SP in gastric antrum

FGB

IRI and FINS of rats in model group had significant difference（ P < 0. 05 or P < 0. 01）. Comparing with model group

gastric residual rate and content of VIP in gastric antrum in Banxia Xiexin Tang high and middle dose groups decreased obviously; SS in gastric antrum

FGB and IRI in Banxia Xiexin Tang high

middle and low dose groups decreased obviously while content of MOT and SP in gastric antrum increased obviously（ P < 0. 05 or P < 0. 01）; alvine pushing rate in Banxia Xiexin Tang middle dose group increased significantly（ P < 0. 05）. Conclusion Banxia Xiexin Tang could promote the recovery of gastrointestinal motility of DM rats

which may related to decreasing blood glucose

improving insulin resistance and gastrointestinal hormones.