Objective To observe clinical effects and its influencing factors of acute cerebral infarction with myocardial ischemia treated by Naoxintong Capsule. Methods Totally 528 patients with acute cerebral infarction with myocardial ischemia were divided into 291 cases in treatment group and 237 cases in control group. The control group was given western medicine to conventional treatment. The treatment group

on the basis of conventional treatment

took Naoxintong Capsule

4 tablets each time（ 0. 4 g each tablet）

three times a day for 12 weeks. The researchers used the national institutes of health stroke scale（ NIHSS） and modified Rankin to compare neurological function of both groups before and after the treatment

as well as compared curative effect in myocardial ischemia and neurological function of two groups after the treatment

and used Logistic regression analysis method to explore influencing factors of curative effect. Results After treatment for 8 weeks and 12 weeks

in the treatment group curative effect of myocardial ischemia took effect accounting for 27. 7% and 31. 3% respectively

that in the control group accounting for13. 9% and 16. 9% respectively. Effective rate of myocardial ischemia in the treatment group were significantly higher than in the control group（ P < 0. 01）. According to the score of NIHSS and modified Rankin

effective rate of neurological deficit in the treatment group were significantly higher than in the control group（ P < 0. 05）. Multi-factor analysis showed that the influencing factors of myocardial ischemia improved involved the therapy of Naoxintong（ P =0. 005） and the level of aspartate transaminase（ AST） at the 12 th weeks（ P = 0. 047）. The influencing factors of neurological function improvement involved the treatment of Naoxintong

baseline systolic pressure and the level of creatinine

past heart disease or hyperlipidemia history. Conclusion Clinical effects of Naoxintong Capsule to treat acute cerebral infarction with myocardial ischemia is definite and can be impacted by past correlative medical history and symptoms.