疏肝益肾方加减联合放化疗对三阴乳腺癌患者免疫调控及生活质量的影响

郑巧; 崔飞飞; 卢雯平

doi:10.13288/j.11-2166/r.2015.20.009

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疏肝益肾方加减联合放化疗对三阴乳腺癌患者免疫调控及生活质量的影响

临床研究 | 更新时间：2021-11-17

- 疏肝益肾方加减联合放化疗对三阴乳腺癌患者免疫调控及生活质量的影响
- Impact of Modified Shugan Yishen Fang（疏肝益肾方） Combined with Radiotherapy and Chemotherapy on Immune Regulation and Quality of Life of Patients with Triple Negative Breast Cancer
- 中医杂志 2015年56卷第20期页码：1742-1745
- 作者机构：
  
  中国中医科学院广安门医院
- 作者简介：
- 基金信息：
  
  国家自然科学基金（81473566）
- DOI：10.13288/j.11-2166/r.2015.20.009
  中图分类号： R737.9
- 纸质出版：2015
- 稿件说明：
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[1]郑巧,崔飞飞,卢雯平.疏肝益肾方加减联合放化疗对三阴乳腺癌患者免疫调控及生活质量的影响[J].中医杂志,2015,56(20):1742-1745.

ZHENG Qiao, CUI Feifei, LU Wenping. Impact of Modified Shugan Yishen Fang（疏肝益肾方） Combined with Radiotherapy and Chemotherapy on Immune Regulation and Quality of Life of Patients with Triple Negative Breast Cancer[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1742-1745.
[1]郑巧,崔飞飞,卢雯平.疏肝益肾方加减联合放化疗对三阴乳腺癌患者免疫调控及生活质量的影响[J].中医杂志,2015,56(20):1742-1745. DOI： 10.13288/j.11-2166/r.2015.20.009.

ZHENG Qiao, CUI Feifei, LU Wenping. Impact of Modified Shugan Yishen Fang（疏肝益肾方） Combined with Radiotherapy and Chemotherapy on Immune Regulation and Quality of Life of Patients with Triple Negative Breast Cancer[J]. Journal of Traditional Chinese Medicine2015, 56(20): 1742-1745. DOI： 10.13288/j.11-2166/r.2015.20.009.

摘要

目的观察疏肝益肾方加减对三阴乳腺癌患者免疫功能及生活质量的影响。方法 30例三阴乳腺癌改良根治术后患者

均给予疏肝益肾方加减

每日1剂

服药2个月;同时给予6

周TAC方案或Acweeky T化疗方案。观察治疗后患者生活质量、症状的改善情况

并比较治疗前后调节性T细胞、细胞毒T细胞、抑制性T细胞和自然杀伤细胞水平变化。结果治疗后调节性T细胞和抑制性T细胞均明显减少

而细胞毒T细胞和自然杀伤细胞均明显增多（P

0.05）;一般健康相关生活质量调查量表8个维度的评分均明显升高（P

0.05）;潮热、盗汗、骨痛、失眠症状的发生比例均明显下降（P

0.05）。结论疏肝益肾方加减联合放疗、化疗可以增强三阴乳腺癌患者的免疫应答能力及减轻免疫抑制作用

提高患者生活质量

缓解症状。

Abstract

Objective To observe the impact of modified Shugan Yishen Fang on immune function and quality of life of patients with triple negative breast cancer（ TNBC）. Methods Totally 30 TNBC patients were given modified Shugan Yishen Fang after modified radical mastectomy

one dose every day

for 2 months. Meanwhile

they were given chemotherapy regimen of TAC or AC weekly T for 6 to 8 weeks. The improvement in quality of life and symptoms were observed. Changes in the levels of regulatory T Cells

cytotoxic T cells

suppressor T cells and natural killer cells before and after treatment were compared. Results Levels of regulatory T Cells and suppressor T cells decreased

while cytotoxic T cells and natural killer cells increased after treatment（ P < 0. 05）. Scores of eight dimensions in the Medical Outcomes Study 36-Item Short Form Health Survey（ SF-36） increased（ P < 0. 05）. The occurring ratio of hectic fever

night sweat

bone pain and insomnia decreased（ P < 0. 05）. Conclusion Modified Shugan Yishen Fang combined with radiotherapy and chemotherapy could promote immunologic responsibility

reduce immunosuppression effect

improve quality of life

and relieve symptoms in TNBC patients.

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