Objective To explore the possible mechanism of Shengqing Jiangzhuo Fang in the treatment of chronic renal failure（ CRF）. Methods Totally 160 Sprague Dawley rats were randomly divided into blank group（ n =40）

CRF model group（ n = 40）

oxyamyli tectus group（ n = 40） and Shengqing Jiangzhuo Fang group（ n = 40）.CRF models were established in every group adopting the method of 5 /6 nephrectomy except in blank group. Oxyamyli tectus group was given 0. 04 g of oxyamyli tectus aldehydum by gavage once every day. Shengqing Jiangzhuo Fang group was given 1 ml /100 g of Shengqing Jiangzhuo Fang solution（ concentration 1 g / ml） by gavage once every day.Blank group and CRF model group were given equivalent normal saline by gavage. All the treatments were lasted for28 days. Serum samples of rats were collected in each group. Renal function

including creatinine（ SCr）

urea nitrogen（ BUN） and uric acid（ UA）

and biochemical indexes

including interleukin1（ IL-1）

interleukin6（ IL-6）and tumor necrosis factorα（ TNFα） were detected. The pathological sections of rats’ renal tissues were observed.Results BUN

UA and TNF-α of rats in CRF model group increased more significantly than those in blank group（ P < 0. 05 or P < 0. 01）. UA and TNF-α of rats in oxyamyli tectus group and Shengqing Jiangzhuo Fang group were lower than those in CRF model group（ P < 0. 05 or P < 0. 01）. UA and TNF-α in Shengqing Jiangzhuo Fang group decreased more significantly than those in oxyamyli tectus group（ P < 0. 05 or P < 0. 01）. Pathological sections showed compensatory hypertrophy glomerulus hyperemia

significant renal tubular epithelium edema

visible focal renal tubular epithelium exuviation

less renal interstitium inflammatory cells infiltration density in rats in Shengqing Jiangzhuo Fang group

and atrophic glomerulus in this group was much less than those in other groups. Conclusion Shengqing Jiangzhuo Fang might block the development of CRF and improve renal function by regulating inflammatory factors of IL-6 and TNF-α.