Objective To explore the impact of Yigong Powder on iron metabolism disorder induced by inflammation. Methods 40 C57 BL /6 mice were randomly divided into control group（ n = 10）

Yigong Powder group（ n = 10）

lipopolysaccharide group（ n = 10） and Yigong Powder combined with lipopolysaccharide group（ n = 10）.Yigong Powder group and Yigong Powder combined with lipopolysaccharide group were given 10. 57 g /（ kg ·d） of Yigong Powder by gavage. Control group was given 0. 2 ml of ultrapure water

all for seven days. On the eighth day

lipopolysaccharide group and Yigong Powder combined with lipopolysaccharide group were given 1. 5 mg / kg of lipopolysaccharide by intraperitoneal injection to establish iron metabolism disorder models. Six hours later

all mice were sacrificed. Blood routine

serum levels of iron and interleukin 6（ IL-6）

and content of iron and IL-6 in liver tissue were detected. Results Blood routine changed little in every group（ P > 0. 05）. Compared with control group

serum level of iron decreased

serum level of IL-6

as well as content of iron and IL-6 in liver tissue increased in lipopolysaccharide group（ P < 0. 05）. Compared with lipopolysaccharide group

iron content in liver tissue

as well as IL-6 in serum and liver tissue decreased in Yigong Powder combined with lipopolysaccharide group（ P < 0. 05）.Conclusion Yigong Powder could improve iron metabolism disorder mediated by lipopolysaccharide under acute inflammation. The mechanism may relate to decrease of IL-6 in serum and liver tissue.