Objective To observe the possible function mechanism of Fushengong Formula in treating chronic renal failure. Methods Fifty-five Sprague Dawley rats were randomly divided into normal group

model group and low

middle and high Fushengong Formula groups

with 11 rats in each. Normal group ate freely. Other 4 groups of rats were fed with fodder containing 0. 5% adenine to make chronic renal failure model. The normal and model groups were orally gavaged with normal saline 20 ml / kg after modeling; while the low

middle and high Fushengong Formula groups were orally gavaged with 4

8

or 16 g / kg of Fushengong Formula respectively

once per day

for 30 days.Serum levels of creatinine（ SCr） and urea nitrogen（ BUN） of rats in each group were tested. Kidney tissue morphology change was observed through HE dyeing. Expression levels of sonic hedgehog（ Shh） and glioma related cancer gene homologous proteins 1（ Gli1） were tested immunohistochemically. Results Serum levels of SCr and BUN and expression levels of Shh and Gli1 in renal interstitium of rats increased remarkably（ P < 0. 05）

and there appeared obvious fibrotic lesions in renal interstitium in model group compared with those in normal group. Serum levels of SCr and BUN and expression levels of Shh and Gli1 of rats in each dose of Fushengong Formula group decreased remarkably compared with that in model group（ P < 0. 05）

especially in high-dose Fushengong Formula group. There was statistically significant differences in those indexes between each two Fushengong Formula groups（ P < 0. 05）.Conclusion Fushengong Formula could remarkably improve renal function of rats with chronic renal failure. And the improving effects were better when dose increased. Its possible mechanism may have a relationship with inhibiting activating Shh signal pathway.