Objective To explore the possible mechanisms of Dongfang Weiyao Capsule（ 东方胃药胶囊

DFWYC）to protect gastric mucosal lesion. Methods Seventy Wistar rats were randomly divided into normal group with 10 rats

and model group

western medicine group and low

medium and high dose of DFWYC groups

with 12 rats in each group. Except from the normal group

the other rats were injected with 100% ice acetic into the junction of gastric antrum and gastric body to build gastric ulcer models. From the 2nd days after the modeing

the normal group and the model group were given 1. 25 ml /100 g of normal saline to gavage

the low

medium and high dose of DFWYC groups were given 0. 17

0. 28

0. 39 g /100 g of DFWYC respectively to gavage

and the western medicine group was given 0. 042 g /100 g of cimetidine tablets to gavage

all once a day for consecutive 14 days. The general conditions of rats in each group were observed and the body weight of rats was recorded. 24 hours after the last dose

the quantity of gastric secretion

gastric acidity and the area of ulcer were measured

the index and inhibition rate of ulcer were calculated

and the expression of epidermal growth factor（ EGF） and epidermal growth factor receptor（ EGFR） in the stomach tissue of those rats were detected. Results Compared with the model group

the body weight of rats increased obviously and the quantity of gastric secretion

gastric acidity

the index of ulcer and the area of ulcer deceased in the cimetidine group and the high dose of DFWYC group（ P < 0. 01）. The inhibition rate of ulcer in the cimetidine group and the high

medium and low dose of DFWYC group were 52. 3%

30. 5%

26. 8% and 17. 4%

respectively. There was dose-dependent relation of the inhibition rate of ulcer among the each dose of DFWYC groups（ P < 0. 01）. Compared with in the normal group

the expression of EGF and EGFR in gastric mucosal tissue increased in the model group and the each dose group（ P < 0. 01）. Conclusion DFWYC may obviously reduce the quantity of gastric secretion and the gastric acidity in rats with gastric mucosal lesion to promote healing ulcer.