Objective To explore the possible mechanism of Yifei Xuanfei Jiangzhuo Formula（ 益肺宣肺降浊方）treating vascular dementia（ VD）. Methods Before modeling

24 rats among 165 SD rats were randomized into sham operation group. The other 141 rats were established VD models by the method of bilateral common carotid artery ligation to block blood circulation. Ninety-six successfully modeled rats were randomized into Chinese medicine high

middle and low dose groups

model group

huperzine A group and piracetam group

16 rats in each group. On the 15 th day of modeling

rats were given medicine by gavage. Chinese medicine high

middle and low dose groups were given Yifei Xuanfei Jiangzhuo Formula 24. 36

12. 18 and 6. 09 g /（ kg ·d） respectively. Huperzine A group and piracetam group were given Huperzine A and piracetam tablets 0. 15 mg /（ kg·d） respectively. Model group and sham operation group were given equivalent double distilled water. After 30 days of administration by gavage

detect the expressions of rats’ brain tissues hippocampus Calmodulin-dependent protein kinases Ⅱ（ Ca MPK-Ⅱ） and synapsin with western blot method. Results The expressions of brain tissues hippocampus Ca MPK-Ⅱ and synapsin in model group were lower than those in sham operation group（ P < 0. 05）. The expressions of Ca MPK-Ⅱand synapsin in Huperzine A group

piracetam group

Chinese medicine high

middle and low dose groups were higher than those in model group（ P < 0. 05）. The increase in Chinese medicine high dose group was the most significant（ P < 0. 05）.Conclusion Yifei Xuanfei Jiangzhuo Formula might up-regulate brain tissue hippocampus Ca MPK-Ⅱ and synapsin expressions and improve study and memorization function to treat VD.