Objective To explore the concerted application and characteristics of contrary herbal drugs Fuzi（ Radix aconiti carmichaeli

附子） and Banxia（ Pinellia ternate

半夏） applied in one prescription. Methods All published literature on Fuzi and Banxia applied in one prescription searched from China National Knowledge Infrastructure（ CNKI）

Wan Fang Data and VIP Database was reviewed. Information in the collected literature

such as case number

diseases and herbs

was extracted to establish a database. Diseases and the relevant systems

as well as main symptoms treated with Fuzi and Banxia applied in one prescription were analyzied adopting descriptive analysis method. Drug pairs and core drug groups in the prescriptions with Fuzi and Banxia were analyzied with association rules technique. Results Totally 1295 papers were included in

with 30042 patients involved. In those literature Fuzi and Banxia were mainly prescribed in the same formular for cough and asthma（ 176 papers

13. 59%）

chest bi（ 86 papers

6. 64%）

and gastritis and stomachache（ 77 papers

5. 95%）. Diseases treated mainly belonged to digestive system conditions（ 290 papers

22. 39%）

cardiovascular diseases（ 260 papers

20. 07%） and respiratory diseases（ 208 papers

16. 06%）. Patients treated with Fuzi and Banxia commonly got cough and asthma

chronic gastritis and chest bi. Results of associated analysis showed that core herbs that applied together with Fuzi and Banxia in the same prescription were Gancao（ Radix Glycyrrhizae

甘 草）

Fuling（ Poria

茯 苓）

Ganjiang（ Rhizoma Zingiberis

干姜）

Baizhu（ Rhizoma Atractylodis Macrocephalae

白 术）

Guizhi（ Ramulus Cinnamomi

桂 枝）

Chenpi（ Pericarpium Citri Reticulatae

陈皮）

Dangshen（ Radix Codonopsis

党参）

Xixin（ Herba Asari

细辛）.Core drug pairs were Fuzi and Banxia

Fuzi and Gancao

Banxia and Gancao

Fuzi and Ganjiang

Banxia and Ganjiang

Banxia and Baizhu. Three papers reported that there were side effects in the concerted application of Fuzi and Banxia in same prescriptions. Conclusion The concerted application of contrary herbal drugs Fuzi and Banxia are mostly for cough and asthma

chronic gastritis

chest bi and other respiratory

digestive and cardiovascular diseases.Herbs of invigorating Qi

strengthening spleen and warming the middle-jiao are often combined with Fuzi and Banxia.The concerted application of Fuzi and Banxia should be used cautiously.