Objective To evaluate the effects of Kangyou Heji（ 抗幽合剂） combined with quadri-combination therapy on helicobacter-pylori（ Hp） eradication rate in patients with chronic gastritis combined with positive Hp.Methods Seventy-five patients with chronic gastritis with positive Hp were randomly divided into a control group

a syndrome differentiation group

and an anti-Hp group（ 25 cases in each group）. The control group was given the quadruple therapy（ omeprazole enteric capsules 20 mg each time

amoxil capsules 1 g each time or clarithromycin capsules 500 mg each time

levofloxacin tablets 200 mg each time

bismuth potassium citrate electuary 220 mg each time） twice a day. The syndrome differentiation group was given the quadruple therapy combined with Chinese medical syndrome differentiation decoction

one dose a day

take half dose each and twice a day. The anti-Hp group was given the quadruple therapy combined with Kangyou Heji one dose a day

take half dose each and twice a day. Each group was treated for 14 days. The researchers respectively evaluated The main symptom scores

scores of patientreported outcome（ PRO） in Chinese medicine for patients with spleen and stomach disease

and safety indexes such as routine of blood

urine

and stool

and liver and renal function of each group before and after the treatments. On the 30 th day after stopping medication

Hp turning-negative rate of patients was tested in each group. Results After treatment

result of Hp test was negative in 17 cases in the control group

with the rate of Hp eradication of68. 0%. And there were 23 cases（ 95. 8%） with Hp negative in the anti-Hp group and 19 cases（ 76. 0%） in the syndrome differentiation group. The rates of Hp eradication in the anti-Hp group and in the syndrome differentiation group were much higher than that in the control group（ P < 0. 01）. After treatment

the main symptom scores

as well as each symptom score

dimensionality

and total scores in PRO scale of patients in each group significantly decreased（ P < 0. 05 or P < 0. 01）. After treatment

there was no statistically significant difference between the each two groups（ P > 0. 05）. There was no significant difference in safety indexes before and after treatment in each group（ P >0. 05）. Conclusion Kangyou Heji combined with quadri-combination therapy may improve Hp eradication rate of patients with chronic gastritis and positive Hp

and may safely and effectively improve clinical symptoms of patients.