Objective To observe short-term curative effects and safety of treatment with cytokine-induced killer cells（ CIK） combined with Xiaoyan Tang on patients with lung cancer who give up chemoradiotherapy. Methods Sixty patients with lung cancer who gave up chemoradiotherapy were selected and given CIK therapy for 18 days.These patients started to take Xiaoyan Tang

one dose a day since one week before blood collection until the end of CIK therapy

totally for 25 days. After the treatment

the relations between patients’ gender

age

pathology

clinical stages and curative effects were analyzed. The improvement in depression

physical strength

sleep

and appetite was also observed

and the levels of D dimer（ D-D2）

fibrinogen（ Fb）

carcino-embryonic antigen（ CEA）

cell keratin19 fragment

alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST）

γ-glutamyltransferase（ GGT）

urea（ UREA） and creatinine（ CREA） before and after treatment were compared. Results The effective rate in female patients was obviously higher than that in male（ P < 0. 05）. There were statistically significant differences in control rates between age < 65 and age ≥ 65

between squamous carcinoma and adenocarcinoma

between compound carcinoma and adenocarcinoma

and between stage Ⅰ and stage Ⅳ（ P < 0. 05）. The improvement rates of living quality about depression

fatigue

insomnia and poor appetite respectively was 56. 3%

58. 1%

53. 6% and55. 0%. There were no statistically significant differences in levels of CEA

cell keratin 19 fragment

D-D2

Fb

ALT

AST

GGT and UREA before and after treatment（ P > 0. 05）. And the level of CREA significantly decreased than that before treatment（ P < 0. 05）. Conclusion CIK combined with Xiaoyan Tang may improve living quality and prognosis

protect hepatorenal function in patients with lung cancer but giving up chemoradiotherapy

with no obvious adverse reactions.