Objective To systematically evaluate clinical effects and safety of Yiqi Fumai Injection（ lyophilization） combined with conventional western medicine for chronic heart failure. Methods China journal full-text database

Chinese technical journal full-text database

Wanfang database

Chinese biomedical literature database

EMBASE

Pub Med and The Cochrane Library were searched from the time databases were built until January 2015 to identify the randomized controlled clinical studies on Yiqi Fumai Injection（ lyophilization） combined with conventional western medicine to treat heart failure. The unified forms were used to collect information such as patients’ general data

intervention measure and observational index. The bias-risk assessment tools provided by Cochrane collaboration network were applied to make methodological quality assessment for the including studies. Rev Man 5. 2. 6 was used for Meta analysis on clinical comprehensive effects

cardiac functional grading

left ventricular ejection fraction

left ventricular end-diastolic diameter and amino-terminal pro-brain natriuretic peptide of patients. Results Eighteen articles were indentified

with 1939 patients involved in. The quality of literature was poor. Results of meta analysis showed that combined with Yiqi Fumai Injection（ lyophilization） into the treatment of chronic heart failure may improve clinical comprehensive effects [OR = 3. 63

95% CI（ 2. 22

5. 93）

P < 0. 001]

improve cardiac function[OR = 1. 98

95% CI（ 1. 48

2. 65）

P < 0. 001]

increase left ventricular ejection fraction [WMD = 4. 35

95%CI（ 3. 32

5. 38）

P < 0. 001]

lower left ventricular end-diastolic diameter [WMD =- 2. 59

95% CI（- 4. 97

- 0. 21）

P < 0. 03 ]

and reduce amino-terminal pro-brain natriuretic peptide [WMD =- 298. 41

95% CI（- 453. 86

- 142. 97）

P0. 0002). Conclusion Based on those indentified studies

Yiqi Fumai Injection（ lyophilization） combined with conventional western medicine to treat chronic heart failure may further improve symptoms and cardiac function

and improve clinical effects.