Objective To observe the clinical efficacy and safety of Qing Li Huazhuo Fang combined with bismuth-quadruple in the treatment of chronic non-atrophic gastritis with helicobacter pylori（ Hp） with damp heat in the spleen and the stomach syndrome. Methods Eighty cases of chronic non-atrophic gastritis with Hp were randomly divided into a treatment group and a control group

with 40 cases in each group. Both groups were given bismuth-quadruple therapy（ 20 mg of rabeprazole enteric capsules

914 mg of amoxicillin clavulanate potassium dispersible tablets

200 mg of metronidazole

and 200 mg of colloidal bismuth pectin capsules

twice a day）

and the treatment group also used Qing Li Huazhuo Fang

one dose daily. Both groups were treated for 14 days. Before and after treatment

changes of gastric mucosa and pathological change under gastroscope

scores of Chinese medical symptoms（ including epigastric pain

epigastric distention

bitter taste

acid regurgitation and viscous faeces）

eradicated rate of Hp

and adverse reactions were observed in two groups

and the clinical efficacy was evaluated.Results The total effective rate in the treatment group was 90. 0%

which was significantly higher than 77. 5% in the control group（ P < 0. 05）. After treatment

the scores of Chinese medical symptoms in the treatment group decreased significantly and were significantly lower than those in the control group（ P < 0. 05 or P < 0. 01）. Eradicated rate of Hp in the treatment group was 92. 5%

which was obviously higher than 77. 5% in the control group（ P <0. 05）. No serious adverse reactions were found in both groups. Conclusion There is definite curative effect of Qing Li Huazhuo Fang combined with bismuth-quadruple in treating chronic non-atrophic gastritis with Hp with damp heat in the spleen and the stomach syndrome. It can significantly improve clinical symptoms and eradicated rate of Hp with good safety.