Objective To observe the clinical efficacy and safety of Tianlou Detoxification Detumescence Powder（ 天楼解毒消肿散） on diabetic foot. Methods One hundred and fifty cases of diabetic foot patients were randomly divided into the treatment group with 100 cases and the control group with 50 cases. Two groups of patients were given basic treatment

the treatment group was treated with Tianlou Detoxification Detumescence Powder directly applied to the ulcer

the control group was treated with Ruyi Jinhuang Powder（ 如意金黄散） smeared onto the affected part or with Ruyi Jinhuang Powder mixed with Vaseline spread onto the gauze and attached to the ulcer. Both groups were treated 1 time daily for 4 weeks. The clinical symptom score and the ulcer area of the two groups before and after treatment and the TCM syndrome curative effect after treatment were compared. Results The Chinese medicine syndrome total effective rate was 91% and 72% in the treatment group and control group respectively

the treatment group was significantly superior to the control group（ P < 0. 05）. After treatment

the scope of lesions

swelling potential

fever

pain

the nature of sepsis

carrion generation

the total symptom score and ulcer area of the two groups were significantly decreased（ P < 0. 51）

and the treatment group was significantly superior to the control group（ P < 0. 05）. Conclusion Tianlou Detoxification Detumescence Powder can effectively improve the clinical symptoms of patients with diabetic foot

which can reduce the ulcer area and has good security.