Objective To explore and discuss the clinical characteristic of refractory gastroesophageal reflux disease. Methods Fifty-one patients with gastroesophageal reflux disease

treated with proton pump inhibitor which turned to be effective

were taken as the control group

while 103 ineffective cases were taken as the refractory group.Observed normal information

related symptoms of gastroesophageal reflux disease of patients in two groups. Adopted self-rating anxiety scale（ SAS） and self-rating depression scale（ SDS） to evaluated patients’ mental and psychological state. Conducted gastroscopic observation. Recorded Helicobacter pylori infection condition

esophageal mucosa inflammation grading under gastroscope and Barrett esophagus condition. Results The difference of gender

age

disease course and body mass index of patients between two groups no statistical significance（ P > 0. 05）. The occurrence rate of patients’ poststernal pain

belching

laryngeal obstruction feel

bucking and coughing symptom and phlegm blockage with Qi stagnation syndrome of the refractory group was remarkably higher than that of the control group

while that of heartburn was lower than the control group（ P < 0. 05）. The number of patients combined with anxiety and depression in the refractory group was remarkably more than that of the control group（ P < 0. 05）. The difference of esophageal mucosa inflammation grading under gastroscope

Barrett esophagus and the number of combing Helicobacter pylori infection between two groups had no statistical significance（ P > 0. 05）. Conclusion Compared with patients with gastroesophageal reflux disease treated with proton pump inhibitor which turned to be effective

the clinical manifestation of patients with refractory gastroesophageal reflux disease was mostly pain

belching

laryngeal obstruction feel

bucking and coughing symptom

and phlegm blockage with Qi stagnation syndrome. These patients were more easily to be have psychological diseases.