Objective To observe effects of Qingre Ditan Jiejing Fang（ 清热涤痰解痉方） on mice with hyperlipemia and coronary artery spasm induced by pituitrin and study the possible mechanism. Methods Totally 140C57 BL /6J mice were randomly divided into normal group

model group

diltiazem group

atorvastatin group and Chinese medicine high

medium and low dose group

with 20 mice in each group. Except for the normal group

the rest groups were given high-fat fodder to feed for 4 weeks. The Chinese medicine high

medium and low dose group were respectively given granules of Qingre Ditan Jiejing Fang

7. 2

3. 6

1. 8 g /（ kg·d）. The diltiazem group was given diltiazem

0. 04 g /（ kg·d）. The atorvastatin group was given atorvastatin calcium tablet

0. 013 g /（ kg · d）. The normal group and the model group were given 0. 5% sodium carboxymethyl cellulose solution with same volume

once a day for four weeks. One hour after the last given treatment

the mice were given intraperitoneal injection with pituitrin 60 U / kg to establish model of coronary artery spasm. The researchers recorded Ⅱ-lead electrocardiogram at the time that 10 min before and 5

10

15 min after injection and counted displacement of T wave. The researchers detected level of serum oxidized low density lipoprotein（ ox-LDL）

high-sensitivity C-reactive protein（ hs-CRP） and endothelin-1（ ET-1） after test. Results At the time that 5

10

15 min after intraperitoneal injection with pituitrin

in the model group

displacement of T wave in electrocardiogram significantly increased compared with the normal group（ P < 0. 05）; Compared with the model group

the diltiazem group

the atorvastatin group and the Chinese medicine high

medium and low dose group at above three time all can lower displacement of T wave（ P < 0. 05）; Compared with the atorvastatin group

displacement of T wave significantly decreased in the Chinese medicine high and medium dose group at the 5

10 min and the Chinese medicine high dose group at the 15 min（ P < 0. 05）. Compared with the normal group

serum ox-LDL

hs-CRP

ET-1 in the rest groups significantly increased（ P < 0. 05 or P < 0. 01）.Compared with the model group

ox-LDL in the Chinese medicine high dose group and the atorvastatin group significantly decreased

hs-CRP in each group that been given medicines significantly decreased and ET-1 in the diltiazem group and the Chinese medicine high dose group significantly decreased（ P < 0. 05）. Conclusions Qingre Ditan Jiejing Fang may effectively relieve pituitrin inducing coronary artery spasm of mice with hyperlipemia and its mechanism may be related to lowering serum ox-LDL

hs-CRP and ET-1.