Impact of Modified Xuefu Zhuyu Decoction( 血府逐瘀汤) on Cardiovascular Events in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention
YANG Hua, XU Chenhong, LI Xin. Impact of Modified Xuefu Zhuyu Decoction( 血府逐瘀汤) on Cardiovascular Events in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention[J]. Journal of Traditional Chinese Medicine2016, 57(7): 592-595.
YANG Hua, XU Chenhong, LI Xin. Impact of Modified Xuefu Zhuyu Decoction( 血府逐瘀汤) on Cardiovascular Events in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention[J]. Journal of Traditional Chinese Medicine2016, 57(7): 592-595.DOI: 10.13288/j.11-2166/r.2016.07.014.
Objective To explore the impact of modified Xuefu Zhuyu Decoction( 血府逐瘀汤) on inflammatory factors and cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention( PCI). Methods Seventy patients with acute coronary syndrome after PCI were randomized into the observation group( 35 cases) and the control group( 35 cases). The control group was treated with coronary heart disease secondary prevention after PCI. Based on this treatment
the observation group was added modified Xuefu Zhuyu Decoction
1 dose every day. Both groups were treated for 8 weeks. Compared triglyceride( TG)
total cholesterol( TC)
high density lipoprotein cholesterol( HDL-C)
low density lipoprotein cholesterol( LDL-C)
troponin Ⅰ( CTnⅠ)
tumor necrosis factorα( TNF-α) and high-sensitivity C-Reactive Protein( hs-CRP) in both groups before and after treatment. Followed up for 12 months and recorded patients’ onset of cardiovascular events during follow-up.Results TC
LDL-C
TNF-α
s CRP and CTnⅠin both groups decreased significantly after treatment( P < 0. 05).TC
LDL-C
TNF-α
hs-CRP and CTnⅠin the observation group were significantly lower than those in the control group( P < 0. 05). The recurrence rate of angina pectoris
the rehospitalization rate and the recurrence rate of myocardial infarction in the observation group were significantly lower than those in the control group during follow-up( P < 0. 05). Conclusion Modified Xuefu Zhuyu Decoction could regulate the blood lipid level of acute coronary syndrome patients after PCI. Moreover
its anti-inflammatory effect was obvious. It was effective in preventing patients’ cardiovascular events.